Amitraz has critics also

Discussion in 'Bee News' started by Americasbeekeeper, Oct 26, 2012.

  1. Americasbeekeeper

    Americasbeekeeper New Member

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    Putative Dopamine Receptors.
    Three of the newly generated sequences were phylogenetically most similar to invertebrate dopamine receptors. These receptors are preferentially activated by dopamine. Dopamine has also been shown to reduce the response to conditioned stimuli as well as inhibiting retrieval of learned information in Apis mellifera [19].
    Putative 5-HT[SUB]7[/SUB] Receptor. It has also been shown to reduce conditioned olfactory responses in the honeybee Apis mellifera [19], [21].

    1. Mercer AR, Menzel R (1982) The effect of biogenic amines on conditioned and unconditioned responses to olfactory stimuli in the honeybee Apis mellifera. J Comp Physiol A 145: 363–368. Find this article online
    The mode-of-action of amitraz, a chemistry registered for tick and insect control, is presumed to have partial agonistic activity at an octopamine sensitive GPCR [8].
    Alignment of transmembrane domains of Aedes aegypti AaDOP1 and AaDOP2 and other D[SUB]1[/SUB]-like receptors. Aligned receptor amino acid sequences include each of the two D[SUB]1[/SUB]-like receptors reported in Drosophila melanogaster (D-Dop1; DopR99B/DAMB) [30], [31], [40], [44], Apis mellifera (AmDOP1; AmDOP2) [41], Ixodes scapularis (Isdop1; Isdop2) [36], [42], and Homo sapiens (HsD1, HsD5) [39], [76].
    Hauser F, Cazzamali G, Williamson M, Blenau W, Grimmelikhuijzen JP (2006) A review of neurohormone GPCRs present in the fruitfly
    Drosophila melanogaster and the honey bee Apis mellifera. Prog Neurobiol 80: 1–19. Find this article online
    Mustard JA, Blenau W, Hamilton IS, Ward VK, Ebert PR, et al. (2003) Analysis of two D[SUB]1[/SUB]-like dopamine receptors from the honey bee Apis mellifera reveals agonist-independent activity. Mol Brain Res 12: 67–77. Find this article online
    Grohmann L, Blenau W, Erber J, Ebert PR, Strunker T, et al. (2003) Molecular and functional characterization of an octopamine receptor from honeybee (Apis mellifera) brain. J Neurochem 86: 725–735. Find this article online
    Blenau W, Erber J, Baumann A (1998) Characterization of a dopamine receptor from Apis mellifera: Cloning, functional expression, pharmacology, and mRNA localization in the brain. J Neurochem 70: 15–23. Find this article online
    Kokay IC, Ebert PR, Kirchhof BS, Mercer AR (1999) Distribution of dopamine receptors and dopamine receptor homologs in the brain of the honey bee, Apis mellifera L. Microscopy Res Tech 44: 179–189. Find this article online
    Blenau W, Baumann A (2001) Molecular and pharmacological properties of insect biogenic amine receptors: Lessons from Drosophila melanogaster and Apis mellifera. Arch Insect Biochem Physiol 48: 13–38. Find this article online
    Humphries MA, Mustard JA, Hunter SJ, Mercer A, Ward V, et al. (2003) Invertebrate D2 type dopamine receptor exhibits age-based plasticity of expression in the mushroom bodies of the honeybee brain. J Neurobiol 55: 315–330. Find this article online
  2. Daniel Y

    Daniel Y New Member

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    So we will just turn our bees into junkies that can't remember what they are supposed to do?

    I can see it now. bees is pulled over for weaving during flight. Bee Police, "So whats your name buddy" Bee " err uh, Wow Man, where am I?, Look at all the pretty lights". Bee Police, :Where are you coming from and what have you been smoking"? Bee, Hey man I just came from Daves house". Bee Police, : DAVES HOUSE!!! Daves not here".

    Sorry couldn't resist.