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I have never done that although pictures suggest you use one of those large 'turkey basting' syringes and drench the cluster at some prescribed quantity per hive. with spraying (I will assume one of those pump up style sprayers) quantity applied becomes pure guess work.

I have assumed drenching is relatively safe during the early spring but might encourage robbing (and thereby the quantity of drenching material would need to be decreased) during other times of the year.
 
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