Melittin, a promiscuous peptide from Apis mellifera

Discussion in 'Bee News' started by Americasbeekeeper, Oct 10, 2012.

  1. Americasbeekeeper

    Americasbeekeeper New Member

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    Warning really scientific stuff, no dumbing this down
    Structural and Functional Characterization of a Multifunctional Alanine-Rich Peptide Analogue from Pleuronectes americanus
    For melittin, a promiscuous peptide from Apis mellifera [76], it was demonstrated that mutations of arginine and lysine residues changed the total activity, with a major effect on toxicity to mammalian cells, reducing 8-fold the activity of the peptide after modification [77].
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0047047