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Mechanism of Action of Recombinant Acc-Royalisin from Royal Jelly of Asian Honeybee against Gram-Positive Bacteria
Royalisin, a potent antimicrobial peptide (AMP), was first isolated from royal jelly of the Western honeybee Apis mellifera [1]. Royalisin strongly inhibits the growth of Gram-positive bacteria including Clostridium, Corynebacterium, Leuconostoc, Staphylococcus, and Streptococcus at the effective concentration of 1 µM. Royalisin also inhibits other Gram-positive bacteria, such as Bacillus subtilis, Sarcina lutea, American foulbrood caused by a Gram-positive bacterial pathogen, Paenibacillus larvae larvae [7], [8].
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