Systemic IgE-mediated allergic reactions after insect stings immune-mediated

Discussion in 'Bee News' started by Americasbeekeeper, Apr 24, 2013.

  1. Americasbeekeeper

    Americasbeekeeper New Member

    Messages:
    1,126
    Likes Received:
    0
    Trophy Points:
    0
    Vitellogenins Are New High Molecular Weight Components and Allergens (Api m 12 and Ves v 6) of Apis mellifera and Vespula vulgaris Venom
    Anaphylaxis due to hymenoptera stings is one of the most severe clinical outcomes of IgE-mediated hypersensitivity reactions. With the vitellogenins of Apis mellifera and Vespula vulgaris venom a new homologous pair of venom allergens was identified and becomes available for future applications. Due to their allergenic properties the honeybee and the yellow jacket venom vitellogenin were designated as allergens Api m 12 and Ves v 6, respectively.
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062009
     
  2. riverbee

    riverbee Active Member

    Messages:
    3,048
    Likes Received:
    0
    Trophy Points:
    36
    thanks gary for posting this article, it was of special interest to me, and my greatest fear:

    "Although allergic reactions to hymenoptera stings are often considered as a general model for the underlying principles of allergic disease, venom immunotherapy is still hampered by severe systemic side effects and incomplete protection. The identification and detailed characterization of all allergens of hymenoptera venoms might result in an improvement in this field and promote the detailed understanding of the allergological mechanism. Our aim was the identification and detailed immunochemical and allergological characterization of the low abundant IgE-reactive 200 kDa proteins of Apis mellifera and Vespula vulgaris venom."