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Is this a frame i should remove and freeze to kill off varoa, or should i leave it be
I'd uncap a dozen or so and check for varroa first. Yes, freezing drone frames is a recognized method of varroa control, but I don't like doing any kind of treatment without first determining if there's a problem.

As for why they'd build an entire frame of drone cells - could be any of a number of reasons. A colony usually has a sense of when to make drones and how many. If your other frames are relatively drone-free, they may have just decided to group all the drones together on this frame since you provided a starter strip. I was in a hive last week that had stuck drone brood in every available crevice. The frames were beautiful, almost drone free, but prying them loose I tore up lots of drone brood they had built connecting the frames in the upper box to the lower box.
 
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